Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen

BriefDefinitive Report AURICULAR CHONDRITIS IN RATS

Relapsing polychondritis is an inflammatory disease of connective tissue characterized by the destruction of hyaline and elastic cartilages . Although the etiology of this disease is unknown, the demonstration of anti-cartilage antibodies in the sera of patients with this disorder suggests an autoimmune mechanism (1, 2) . Recently, Foidart et al . (3) have reported an association between relaps...

Relapsing Polychondritis Collagen Immunization: A Model for Human Auricular Chondritis Following Type II HLA-DQ6/8 Double Transgenic Mice Develop

Mice expressing HLA-DQ6α8β transgenes develop polychondritis spontaneously

Relapsing polychondritis (RP) is a human autoimmune disease of unknown etiology in which cartilaginous sites are destroyed by cyclic inflammatory episodes beginning, most commonly, during the fourth or fifth decade of life. We have previously described collagen-induced polychondritis that closely mirrors RP occurring in young (6-8 weeks old) HLA-DQ6alphabeta 8alphabeta transgenic Abeta0 mice, f...

The development of trigeminal neuralgia related to auricular chondritis in a patient with rheumatoid arthritis-relapsing polychondritis and its treatment with etanercept. Description of the first case.

Cranial neuropathy is an uncommon manifestation of relapsing polychondritis (RPC). Optic neuropathy is the most common type of cranial nerve involvement in RPC. Until now, trigeminal neuralgia (TN) has been reported with different rheumatic diseases, however, there is no reported case of TN associated with RPC. We here present a case of RPC with TN. A 57 year-old female patient previously diagn...

Recurrent auricular chondritis and cartilage repair.

W e present a case of recurrent auricular chondritis, which developed after two injections of a luteinising hormone-releasing hormone (LH-RH) analogue buserelin combined with oral treatment of a pure antiandrogen bicalutamide (Casodex). The patient was treated successfully with a continuous moderate dose of corticosteroids together with azathioprine and methotrexate. Complete repair of the defo...